Endocrine Abstracts

Glycogen storage disease (GSD) type 1 is an autosomal recessive disorder in which there is problem in glucose 6 phosphatase system. Glucose-6-phosphate transport protein deficiency is found in GSD type 1b. There is disorder in glucose metabolism, lack of glucose production in liver. Hypoglycemia, seizures, lactic acidosis, hyperuricemia and hyperlipidemia are some of the components. Affected people may also have short stature, pancytopenia and inflammatory bowel disease. Our a...

Introduction: Radioiodine ablation with a whole-body scan is a well known therapeutic regimen for differentiated thyroid cancer. I-131 uptake in the breast has been described with a variety of normal and pathologic conditions such as gynecomastia, supernumerary breasts, fibroadenoma and lactational duct cyst or galactocele. Here we report a case with an incidental radioiodine uptake in breast who turned out to be breast cancer.Case report: A 70 years old...

Background: Pregnancy and lactation-related osteoporosis can be associated with fractures during the last trimester or early postpartum period. During lactation, a 3–10% bone loss in the lumbar vertebrae has been detected within 3–6 months. When lactation is reduced bone mineral density(BMD) values reach early postpartum levels within 6–18 months. Certain comorbidities, such as hypercalciuria, premature ovarian failure, low body mass index, oligoamenorrhea, seve...

Background: Although most solid primary tumors can metastasize to the adrenal glands, lung cancer is the most common, followed by renal cell carcinoma, melanoma and colorectal cancer. However endometrial cancer metastasis to adrenal gland is very rare. There are only a few case in literature. Endometrial cancer is the most common gynecological malignancy. In this case, we present a case of adrenal gland metastasis of endometrial cancer.Case presentation:...

Aim: Thyroid hormones have many effects on the cardiovascular system. May studies have showed that apparent or subclinical hypothyroidism increase the risk of hypertension hyperlipidemia and so lead to atherosclerosis susceptibility. This risk can be reduced by treatment. But, studies on the relationship between thyroid function tests and cardiovascular risk in euthyroid subjects are contradictory. This study was designed to investigate the effect of TSH, free T3, f...

Introduction: The aim of this study is to investigate association between Hashimoto’s thyroiditis (HT) and vestibular function and the possible effect of levothyroxine (LT4) treatment on vestibular functionPatients and methods: We recruited 61 patients with HT and 30 age and gender matched healthy individuals for the study. Of 30 patients with HT were on LT4 treatment (group I) and 31 patients were treatment naive (group II). None of the patients ha...

The prevalance of incidentally discovered adrenal masses increased in last three decades. The major clinical concern is the risk of malignancy and hormone overproduction but most of them are non-fonctional and benign. Current practices in the management of adrenal incidentalomas reevaluated the follow-up suggestions considering low probability of the transformation of a benign and non-functional adrenal mass to a malignant or functional one. Therefore, in the present study we ...

Sarcoidosis is a multisystem granulomatous disease of unknown cause. The prevalence of neurosarcoidosis is about 5–15%. Hypothalamo-pituitary sarcoidosis is even rarer (<1% of cases evaluated for sellar and stalk lesions).Case Report: A 33-year-old man presented to urology department with erectile dysfunction which started six months ago. Hormonal evaluation revealed gonadotropin deficiency and hyperprolactinemia (Total testosterone: 30.5 ng/dl,...

Background and aim: Acromegaly is a rare endocrine disease and is associated with an increased prevalence of colorectal cancer and pre-malignant tubular adenomas, and also may be associated with other organ malignancies such as breast and thyroid. We report a rare case of acromegaly concomitant with adenocarcinoma arising from pancreas.Case report: A 52-year-old man who was diagnosed with acromegaly two years ago referred our outpatient clinic. After dia...

Introduction: The risk of malignancy has often been reported to be more frequent in Graves’ disease (GD) than non-autoimmune thyroid nodules. However, frequency of thyroid nodules, diagnostic yield of fine-needle aspiration (FNA), and their potential for bearing malignancy in GD are still debatable issues. We aimed to determine the prevalence, ultrasonographic and cytological features, and the rate of malignancy outcome of thyroid nodules in a group of patients with GD.</...